mother and children

Problematic

  • Only 45% of estimated TB cases in children were notified to the World Health Organization by countries in 2016.
  • A majority of the 250,000 paediatric deaths from TB occur in undiagnosed children under the age of 5.
  • A majority of children with TB are not diagnosed/not reported and do not benefit from appropriate treatment.
  • This is due to the poor access to childhood TB diagnosis in many health centres, especially at district and primary healthcare level in most high-burden countries.
  • It is difficult to diagnose TB from sputum in children because many of them do not produce sputum.
  • There is a lack of good quality radiography.
  • There is a lack of effective, affordable and easy-to-use diagnostic and sample collection tools.
  • There is insufficient qualified health staff.
  • There is no systematic detection of TB in highly vulnerable children (severely malnourished, HIV-infected, and children with severe pneumonia).

The project

The TB-Speed project will carry out research activities aiming at reducing childhood mortality from TB by evaluating innovative and cost-effective TB diagnostic approaches for resource-limited settings. It will be organised around two major axes :

  • Decentralisation of TB diagnosis at district level
  • Systematic TB detection in highly vulnerable children (HIV-infected, severely malnourished, and children with severe pneumonia)

The diagnostic approach will include procurement and use of a molecular diagnosis assay (XpertMTB/RIF Ultra) applied on nasopharyngeal aspirate and stool samples, introduction of digital chest radiography, as well as training and mentoring of clinicians for screening and diagnosis of paediatric TB.

Implemented over a period of four years in seven countries of Africa and Asia (Cambodia, Cameroon, Côte d’Ivoire, Mozambique, Sierra Leone, Uganda, and Zambia), the project will contribute to screening of a total of approximately 77,000 children.

Its multidisciplinary consortium under the leadership of the University of Bordeauxcoordinates with researchers, technical experts, health professionals, public health program managers and Non-Governmental Organizations from both high-income countries and low- and middle-income countries.

map project
stars flowers mother and daughter
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Major areas

Decentralisation of TB diagnosis at district level

Systematic TB detection in vulnerable children

  • Local capacity building for clinical diagnosis of paediatric TB
  • Enhancement of early detection of paediatric TB
  • Increase in the number of reported cases
  • Generation of relevant evidence on public health impact of the strategies